IVIS® SpectrumCT System

IVIS® SpectrumCT System

Preclinical true 3D optical In-vivo imaging system with microCT

The IVIS® SpectrumCT expands upon the versatility and advanced 3D optical feature sets of the IVIS® spectrum by integrating low dose microCT to support longitudinal imaging. The IVIS® SpectrumCT enables simultaneous molecular and anatomical longitudinal studies, providing researchers with essential insights into complex biological systems in small animal models. The constant horizontal gantry motion and the flat panel detector provide unparalleled performance for low-dose imaging and automated optical and microCT integration. The stable revolving animal platform table rotates 360° to acquire full 3D data. Multiple animals can bescanned simultaneously while maintaining an average dose per scan at about 13mGy, with a scanning and reconstruction time of less than a minute. Optical and microCT modalities can also operate independently.

Advanced spectral-unmixing algorithms and a broad range of high spectral resolution filter sets minimize autofluorescence and provide the opportunity to image a wide variety of targeted and activatable fluorescent probes and reporters. Fluorescence imaging can be performed in high-throughput epi-illumination mode or trans-illumination mode to enable deep tissue sourcedetection and quantitation.

IVIS® SpectrumCT offers bioluminescent, Cerenkov and fluorescent imaging for true quantitative and calibrated analysis of optical data. From high-throughput optical screening of 5 mice simultaneously to intricate complex animal modelling, the SpectrumCT offers imaging solutions for a comprehensive array of applications within biomedical areas including oncology, infectious diseases, musculo-skeletal, cardiovascular, neurology and respiratory research.

Key features include:
  • Integrated optical and microCT technology
  • 3D optical tomography for fluorescence and bioluminescence
  • The industry’s most sensitive detection technology ideal for:
  • Bioluminescence
  • Multispectral fluorescence and spectral unmixing
  • Cerenkov imaging for optical radiotracer imaging
  • Low dose and ultra fast microCT
  • DyCE™ dynamic enhanced imaging for real time distribution studies of both fluorochromes or PET tracers ideal for PK/PD app

Instrument Specifications


  • Camera
  • CCD Size
  • Imaging Pixels
  • Quantum Efficiency
  • Pixel Size
  • Minimum Detectable Radiance
  • Min. Field of View (FOV)
  • Max. Field of View (FOV)
  • Min. Image Pixel Resolution
  • Lens
  • Read Noise
  • Dark Current (Typical)
  • Excitation Fluorescence Filters
  • Emission Fluorescence Filters
  • Transillumination Stage
  • 3D Tomography Software
  • CCD Operating Temperature
  • Maximum Energy
  • Focal Spot
  • X-ray Detector
  • Detector Size
  • Detector
  • Detector Operating Temp. Range
  • μCT Field of View
  • Voxel Size
  • Standard Scan Time
  • Standard Reconstruction Time
  • Standard Scan Dose
  • Limiting Resolution (3% MTF)
  • Safety Requirements




Sensor Back-thinned, back-illuminated Grade 1 CCD
2.7 x 2.7 cm
2048 x 2048
> 85% 500-700 nm; > 30% 400-900 nm
13.5 microns
70 photons/s/sr/cm2

3.9 x 3.9 cm

23 x 23 cm

20 microns

f/1 – f/8 1.5x, 2.5x, 5x, 8.7x magnifications
< 3 electrons for bin=1,2,4; < 5 electrons for bin=8,16
< 100 electrons/s/cm2
10

18

yes

Included

-90 °C

Maximum Energy of 50 kV with 1 mA
50 um
CMOS
3072 x 864 pixels
ADC Bit Depth 14 bits
10-40 °C

126 x 126 x 31 to 20 x 20 x 20 (L x W x H, mm)
41 μm – 328 μm
3.6 to 72 seconds
40 to 150 seconds

minimum of ~13mGy
150 μm

Less than 1uSeviert/hour max exposure at 5 cm from anywhere outside cabinet, FDA and TUV approved

Hardware Specifications

  • Imaging Chamber Interior Size
  • Imaging System Space Requirement
  • Power Requirements
  • Stage Temperature
  • Heated Chamber
  • Gas Anesthesia Ports
  • Injector Ports
  • Computer




43 x 50 x 60 cm (W x D x H)

203 x 163 x 214 cm (W x D x H)

20 Amps for 120 VAC or 10 Amps for 230 VAC
20-40 °C
Yes
Yes
Yes
Quad Core 2.8 GHz, 12 GB, 1333 MHz DDR3, SDRAM, 2GB NVIDIA Quadro 4000 with 256 CUDA Cores, I TB hard drive, 20" flat screen monitor
  • Low dose and Ultra-fast MicroCT imaging
  • Multispectral Fluorescent imaging and spectral unmixing
  • Bioluminescence imaging
  • Cerenkov Imaging
  • True 3D topographic imaging
  • Fluorescent agents, Dyes, Labelling Kits, and Nanoparticles
  • Bioluminescent oncology cell lines and bacterial created using luciferase (luc2) vector for utlra brite sensitivity
  • Bioluminescent substrates including D-Luciferin K+ salt and RediJect Luciferin in ready-to-use injectable format
  • Radio imaging reagents
  • Living Image® Software

PerkinElmer's IVIS SpectrumCT Pre-clinical In Vivo Imaging System
In Vivo Bioluminescence Imaging on the IVIS Platform
PerkinElmer's IVIS Spectrum Pre-clinical In Vivo Imaging System